The NFL regular season ends the first quarter with many desperate teams trying to right the ship. Chicago tries to find answers on offense while the Lions and Bills look to stay unbeaten.
Carolina Panthers at Chicago Bears: Jay Cutler needs fast start from Matt Forte
Cam Newton and his Carolina Panthers visit the Chicago Bears for a critical game on both sides. Chicago desperately needs a good outing from running back Matt Forte to help quarterback Jay Cutler, and the banged up Panthers defense can be just the ticket.
Final score: Bears win 28-14
Buffalo Bills at Cincinnati Bengals: Ryan Fitzpatrick looks to continue hot start
Fresh off their emotional win against the Patriots, the Buffalo Bills must maintain focus against a sinking Cincinnati Bengals squad. Quarterback Ryan Fitzpatrick should keep the offense humming while the defense takes aim at rookie Andy Dalton.
Final score: Bills win 34-17
Tennessee Titans at Cleveland Browns: Peyton Hillis or Chris Johnson hold key
This NFL regular season game is difficult to gauge. Both teams come off narrow victories, are 2-1 and have game breakers at running back. For the Tennessee Titans, look for Chris Johnson to get early touches while the Cleveland Browns work Peyton Hillis back into the game plan.
Final score: Browns win 20-17
Detroit Lions at Dallas Cowboys: Tony Romo must contend with Ndamukong Suh
While Matthew Stafford and Calvin Johnson grab headlines, it has been the strength of Ndamukong Suh and the defense that has the Detroit Lions 3-0. Tony Romo and the Dallas Cowboys offensive line must recognize this if they want to avoid a 1-3 start.
Final score: Lions win 28-13
Pittsburgh Steelers at Houston Texans: Texans eye exposed Ben Roethlisberger
Fresh off their humiliating performance in New OrlÃ©ans, the Houston Texans defense returns home against the pitiful Pittsburgh Steelers offensive line. If they get to Ben Roethlisberger like the Colts did on Sunday night, not even the Steelers defense can keep this game from getting away.
Final score: Texans win 26-17
New OrlÃ©ans Saints at Jacksonville Jaguars: Drew Brees must grab early lead
Drew Brees is the main reason the New OrlÃ©ans Saints are 2-1. They meet the Jacksonville Jaguars and rookie Blaine Gabbert who hopes to expose the weak Saints defense with help from running back Maurice Jones-Drew. Brees likely won't let that happen though.
Final score: Saints win 35-20
Minnesota Vikings at Kansas City Chiefs: Adrian Peterson should expect the ball
Once again the Minnesota Vikings opened a game with a big lead and fumbled it away. Part of their problem is refusing to give the ball to their best player. Adrian Peterson will likely run the ball a lot to wear down a Kansas City Chiefs defense shackled to the pathetic Chiefs offense.
Final score: Vikings win 27-14
San Francisco 49ers at Philadelphia Eagles: Health of Michael Vick a huge factor
Michael Vick luckily didn't break his hand last week but shouldn't smile given the tough San Francisco 49ers defense approaches. Philly must invest running the ball with LeSean McCoy to protect Vick while the defense takes care of Alex Smith and the 49ers offense.
Final score: Eagles win 30-10
Washington Redskins at St. Louis Rams: Sam Bradford must get first win alone
With a defense ranked dead last in the league and Steven Jackson hurt, Sam Bradford will have to lead his St. Louis Rams to victory alone. That won't come easy against an angry Washington Redskins team fresh off their disappointing loss on Monday night in Dallas.
Final score: Redskins win 31-28
The NFL regular season late game picks are still to come. Stay tuned.